Deep Sleep Aids Brain Waste Removal to Prevent Neurodegenerative Diseases Leave a comment

A new study reaffirms the importance of getting a good night’s sleep. All animals – especially those in the wild – are incredibly vulnerable when they sleep. But research increasingly shows that the benefits of sleep – including crucial waste removal – outweigh this increased vulnerability.

By examining fruit flies’ brain activity and behavior, the researchers found that deep sleep has an ancient, restorative power to clear waste from the brain. This waste potentially includes toxic proteins that may lead to neurodegenerative disease.

“Waste clearance could be important, in general, for maintaining brain health or for preventing neurogenerative disease,” said Dr. Ravi Allada, senior author of the study.

“Waste clearance may occur during wake and sleep but is substantially enhanced during deep sleep.”

Although fruit flies seem very different from humans, the neurons that govern flies’ sleep-wake cycles are strikingly similar to our own. For this reason, fruit flies have become a well-studied model organism for sleep, circadian rhythms and neurodegenerative diseases.

In the current study, Allada and his team examined proboscis extension sleep (PES), a deep-sleep stage in fruit flies, which is similar to deep, slow-wave sleep in humans. The researchers discovered that, during this stage, fruit flies repeatedly extend and retract their proboscis (or snout).

“This pumping motion moves fluids possibly to the fly version of the kidneys,” Allada said. “Our study shows that this facilitates waste clearance and aids in injury recovery.”

When Allada’s team impaired flies’ deep sleep, the flies were less able to clear an injected non-metabolizable dye from their systems and were more susceptible to traumatic injuries.

Allada said this study brings us closer to understanding the mystery of why all organisms need sleep.

“Our finding that deep sleep serves a role in waste clearance in the fruit fly indicates that waste clearance is an evolutionary conserved core function of sleep. This suggests that waste clearance may have been a function of sleep in the common ancestor of flies and humans.”

Source: Bart van Alphen, Evan R. Semenza, Melvyn Yap, Bruno van Swinderen, Ravi Allada. A deep sleep stage in Drosophila with a functional role in waste clearance. Science Advances, 2021; 7 (4): eabc2999 DOI: 10.1126/sciadv.abc2999

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